Showing posts with label Sepsis. Show all posts
Showing posts with label Sepsis. Show all posts
Wednesday, May 2, 2018

Hollow Hegemony: The Opportunity Costs of Overemphasizing Sepsis

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Protocols are to make complex tasks simple, not simple tasks complex. - Scott K Aberegg Yet here we find ourselves some 16 years af...
Tuesday, February 23, 2016

Much Ado About Nothing? The Relevance of New Sepsis Definitions for Clinical Care Versus Research

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What's in a name?  That which we call a rose, by any other name would smell as sweet. - Shakespeare, Romeo and Juliet Act II Scene I...
3 comments:
Friday, May 1, 2015

Is There a Baby in That Bathwater? Status Quo Bias in Evidence Appraisal in Critical Care

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"But we are not here concerned with hopes and fears, only the truth so far as our reason allows us to discover it."   -   Charles...
Saturday, October 11, 2014

Enrolling Bad Patients After Good: Sunk Cost Bias and the Meta-Analytic Futility Stopping Rule

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Four (relatively) large critical care randomized controlled trials were published early in the NEJM in the last week.  I was excited to b...
1 comment:
Monday, May 19, 2014

Sell Side Bias and Scientific Stockholm Syndrome: A Report from the Annual Meeting of the American Thoracic Society

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What secrets lie inside? Analysts working on Wall Street are sometimes categorized as working on either the "buy side" or the...
2 comments:
Saturday, April 26, 2014

Dear SIRS: Your Septic System Stinks

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I perused with interest the April 2nd JAMA article on the temporal improvement in severe sepsis outcomes in Australia and New Zealand (AN...
1 comment:
Sunday, March 23, 2014

Lost Without a MAP: Blood Pressure Targets in Septic Shock

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Another of the critical care articles published early online at www.nejm.org last week was this trial of High versus Low Blood-Pressur...
1 comment:
Thursday, March 20, 2014

Sepsis Bungles: The Lessons of Early Goal Directed Therapy

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On March 18th, the NEJM published early online three original trials of therapies for the critically ill that will serve as fodder for se...
6 comments:
Monday, November 18, 2013

Dead in the Water: Colloids versus Crystalloids for Fluid Resuscitation in the ICU

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It is a valid question:  at what point has a concept been tested ad infinitum such that further testing is not worthwhile?  There are at le...
2 comments:
Saturday, October 12, 2013

Goldilocks Meets Walter White in the ICU: Finding the Temperature (for Sepsis and Meningitis) that's Just Right

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In the Point / Counterpoint  section of the October issue of Chest, two pairs of authors spar over whether fever should be controlled in s...
Sunday, March 24, 2013

Why Most Clinical Trials Fail: The Case of Eritoran and Immunomodulatory Therapies for Sepsis

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The experimenter's view of the trees. The ACCESS trial of eritoran in the March 20, 2013 issue of JAMA can serve as a springboar...
Thursday, May 24, 2012

Fever, external cooling, biological precedent, and the epistemology of medical evidence

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It is rare occasion that one article allows me to review so many aspects of the epistemology of medical evidence, but alas Schortgen et a...
1 comment:
Thursday, July 9, 2009

No Sham Needed in Sham Trials: Polymyxin B Hemoperfusion in Abdominal Septic Shock (Alternative Title: How Meddling Ethicists Ruin Everything)

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This a superlative article to jab at to demonstrate some interesting points about randomized controlled trials that have more basis in hope ...
1 comment: