Wednesday, November 28, 2018

Speed Matters: Landmark Guided Left Subclavian Vein Central Venous Catheter Insertion

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Here is the occasional cross-post from Status Iatrogenicus for the critical care afficionados following this blog:  Speed Matters:  Land...
Thursday, May 24, 2018

You Have No Idea of the Predictive Value of Weaning Parameters for Extubation Success, and You Probably Never Will

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As Dr. O'brien eloquently described in this post , many people misunderstand the Yang-Tobin (f/Vt) index as being a "weaning para...
1 comment:
Thursday, May 17, 2018

Increasing Disparities in Infant Mortality? How a Narrative Can Hinge on the Choice of Absolute and Relative Change

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An April, 11th, 2018 article in the NYT entitled " Why America's Black Mothers and Babies are in a Life-or-Death Crisis " mak...
Wednesday, May 2, 2018

Hollow Hegemony: The Opportunity Costs of Overemphasizing Sepsis

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Protocols are to make complex tasks simple, not simple tasks complex. - Scott K Aberegg Yet here we find ourselves some 16 years af...
Sunday, April 22, 2018

The Respiratory Rosenhan Experiment on Obese Patients

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Normally this post would be on Status Iatrogenicus , but the implications for "evidence" and the EBM movement are too important, ...
4 comments:
Thursday, February 15, 2018

Ruling Out PE in the ED: Critical Analysis of the PROPER Trial

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This post is going to be an in-depth "journal club" style analysis of the PROPER trial. In this week's JAMA, Freund et ...
Wednesday, November 1, 2017

Applied Respiratory Physiology Vlog. Parts 1,2,3,4: Respiratory Failure Explained as Workload Imbalance

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Here is another cross-post from Status Iatrogenicus that I think is worthwhile for anybody dealing with respiratory failure. Applied Re...
1 comment:
Tuesday, September 26, 2017

DIPSHIS: Diprivan Induced Pseudo-Shock & Hypoxic Illness Syndrome

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Here's the occasional cross-post from Status Iatrogenicus , as it has relevance to research as well as medical practice.  Original post...
Sunday, August 27, 2017

Just Do As I (Vaguely) Say: The Folly of Clinical Practice Guidelines

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If you didn't care to know anything about finance, and you hired a financial adviser (paid hourly, not through commissions, of course) ...
1 comment:
Thursday, April 6, 2017

Why Most True Research Findings Are Useless

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In his provocative essay in PLOS Medicine  over a decade ago, Ioannidis argued that most published research findings are false, owing to ...
1 comment:
Tuesday, April 4, 2017

Tipping the Scales of Noninferiority: Abbott's "Emboshield and Xact Carotid Stent System"

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I just stumbled across this and think it's worth musing over it a bit.  The recently published ACT I trial by Rosenfield et al  is a ...
Friday, February 10, 2017

The Normalization Fallacy: Why Much of “Critical Care” May Be Neither

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Like many starry-eyed medical students, I was drawn to critical care because of the high stakes, its physiological underpinnings, and the ...
6 comments:
Wednesday, January 11, 2017

Don't Get Soaked: The Practical Utility of Predicting Fluid Responsiveness

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In this article in the September 27th issue of JAMA , the authors discuss the rationale and evidence for predicting fluid responsiveness ...
Thursday, January 5, 2017

RCT Autopsy: The Differential Diagnosis of a Negative Trial

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At many institutions, Journal Clubs meet to dissect a trial after its results are published to look for flaws, biases, shortcomings, limi...
2 comments:
Thursday, September 8, 2016

Hiding the Evidence in Plain Sight: One-sided Confidence Intervals and Noninferiority Trials

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In the last post, I linked a video podcast of my explaining non-inferiority trials and their inherent biases.  In this videocast, I revisit...
3 comments: